Journal
APMIS
Volume 118, Issue 1, Pages 1-36Publisher
WILEY
DOI: 10.1111/j.1600-0463.2009.02563.x
Keywords
Penicillin; beta-lactam; penicillin-binding protein; Alexander Fleming; beta-lactamases; amp genes
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Funding
- NIH [S06 GM08205, 5SC1AI081376]
- Florida International University
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [SC1AI081376] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [S06GM008205] Funding Source: NIH RePORTER
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This review focuses on the era of antibiosis that led to a better understanding of bacterial morphology, in particular the cell wall component peptidoglycan. This is an effort to take readers on a tour de force from the concept of antibiosis, to the serendipity of antibiotics, evolution of beta-lactam development, and the molecular biology of antibiotic resistance. These areas of research have culminated in a deeper understanding of microbiology, particularly in the area of bacterial cell wall synthesis and recycling. In spite of this knowledge, which has enabled design of new even more effective therapeutics to combat bacterial infection and has provided new research tools, antibiotic resistance remains a worldwide health care problem.
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