Journal
APMIS
Volume 118, Issue 6-7, Pages 471-493Publisher
WILEY
DOI: 10.1111/j.1600-0463.2010.02618.x
Keywords
Human papillomaviruses; E6; E7; pRB; p53; PDZ proteins; chromosomal instability
Categories
Funding
- Associazione Italiana per la Ricerca sul Cancro
- International Agency for Research on Cancer
Ask authors/readers for more resources
Persistent infection by a subgroup of so-called high-risk human papillomaviruses (HPVs) that have a tropism for mucosal epithelia has been defined as the cause of more than 98% of cervical carcinomas as well as a high proportion of other cancers of the anogenital region. Infection of squamous epithelial tissues in the head and neck region by these same high-risk HPVs is also associated with a subset of cancers. Despite the general conservation of genetic structure amongst all HPV types, infection by the low-risk types, whether in genital or head and neck sites, carries a negligible risk of malignant progression, and infections have a markedly different pathology. In this review, we will examine and discuss the interactions that the principal viral oncoproteins of the high-risk mucosotrophic HPVs and their counterparts from the low-risk group make with cellular target proteins, with a view to explaining the differences in their respective pathology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available