Journal
BIOMACROMOLECULES
Volume 6, Issue 5, Pages 2503-2511Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm050206y
Keywords
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Funding
- NIAMS NIH HHS [R01 AR045871-06, R01 AR045871-05, R01 AR045871, R01 AR45871] Funding Source: Medline
- NIBIB NIH HHS [EB003060, R01 EB003060, R01 EB003060-02, R01 EB003060-01] Funding Source: Medline
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A novel self-cross-linkable and biodegradable macromer, poly(caprolactone fumarate) (PCLF), has been developed for guided bone regeneration. This macromer is a copolymer of fumaryl chloride, which contains double bonds for in-situ cross-linking, and poly(c-caprolactone), which has a flexible chain to facilitate self-cross-linkability. PCLF was characterized with Fourier transform infrared spectroscopy, H-1 and C-13 nuclear magnetic resonance spectroscopy, and gel permeation chromatography. Porous scaffolds were fabricated with sodium chloride particles as the porogen and a chemical initiation system. The PCLF scaffolds were characterized with scanning electron microscopy and micro-computed-tomography. The cytotoxicity and in vivo biocompatibility of PCLF were also assessed. Our results suggest that this novel copolymer, PCLF, is an injectable, self-cross-linkable, and biocompatible macromer that may be potentially used as a scaffold for tissue engineering applications.
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