Journal
APMIS
Volume 117, Issue 5-6, Pages 458-476Publisher
WILEY
DOI: 10.1111/j.1600-0463.2009.02453.x
Keywords
Toxoplasma; host-parasite interactions; apicomplexan; immune response
Categories
Funding
- National Institutes of Health [RO1AI069986]
- American Cancer Society [MBC-114461]
- American Heart Association [0835099N]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI069986] Funding Source: NIH RePORTER
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Blader IJ, Saeij JP. Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence. APMIS 2009; 117: 458-76. Toxoplasma gondii is an obligate intracellular protozoan parasite that can infect most warm-blooded animals and cause severe and life-threatening disease in developing fetuses and in immune-compromised patients. Although Toxoplasma was discovered over 100 years ago, we are only now beginning to appreciate the importance of the role that parasite modulation of its host has on parasite growth, bradyzoite development, immune evasion, and virulence. The goal of this review is to highlight these findings, to develop an integrated model for communication between Toxoplasma and its host, and to discuss new questions that arise out of these studies.
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