Journal
JOURNAL OF NATURAL PRODUCTS
Volume 68, Issue 9, Pages 1397-1399Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np058018g
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From Penicillium janczewskii, obtained from a marine sample, two new diastereomeric quinolinones, 3S*,4R*-dihydroxy-4-(4 '-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (1) and 3R*,4R*-dihydroxy-4-(4 ' methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (2), were identified, along with two known alkaloids, peniprequinolone (3) and 3-methoxy-4-hydroxy-4-(4 '-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (4). Cytotoxicity testing on eight tumor cell lines revealed a moderate specificity of 2 on SKOV-3 cells.
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