Journal
MEDICAL AND VETERINARY ENTOMOLOGY
Volume 19, Issue 3, Pages 333-337Publisher
WILEY
DOI: 10.1111/j.1365-2915.2005.00577.x
Keywords
Lucilia sericata; antibacterial; larval therapy; methicillin-resistant Staphylococcus aureus; secretions
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The antibacterial properties of secretions aseptically collected from larvae of the greenbottle fly Lucilia sericata (Meigen) (Diptera: Calliphoridae) were examined. These investigations revealed the presence of small (< 1 kDa) antibacterial factor(s) within the larval secretions, active against a range of bacteria. These include the Gram-positive Staphylococcus aureus, both methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA), Streptococcus pyogenes and to a lesser extent the Gram-negative Pseudomonas aeruginosa. These secretions were shown to be highly stable as a freeze-dried preparation and, considering the activity against organisms typically associated with clinical infection, may be a source of novel antibiotic-like compounds that may be used for infection control and in the fight against MRSA.
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