4.8 Article

Palladium-catalyzed annulation of arynes by 2-halobenzaldehydes: Synthesis of fluoren-9-ones

Journal

ORGANIC LETTERS
Volume 7, Issue 18, Pages 3973-3976

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol0514597

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Funding

  1. NIGMS NIH HHS [GM 070620] Funding Source: Medline

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Arynes, generated in situ from 2-(trimethylsilyl)aryl triflates and CsF, undergo annulation by o-haloarenecarboxaldehydes in the presence of a Pd catalyst, providing a useful new method for the synthesis of fluoren-9-ones in good yields.

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