Journal
NATURE CELL BIOLOGY
Volume 7, Issue 9, Pages 921-U89Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb1296
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The inhibitor of NF-kappa B ( I kappa B) family of proteins is believed to regulate NF-kappa B activity by cytoplasmic sequestration. We show that in cells depleted of I kappa B alpha, I kappa B beta and I kappa B epsilon proteins, a small fraction of p65 binds DNA and leads to constitutive activation of NF-kappa B target genes, even without stimulation, whereas most of the p65 remains cytoplasmic. These results indicate that although I kappa B alpha, I kappa B beta and I kappa B epsilon proteins could be dispensable for cytoplasmic retention of NF-kappa B, they are essential for preventing NF-kappa B dependent gene expression in the basal state. We also show that in the absence of I kappa B alpha, I kappa B beta and I kappa B epsilon proteins, cytoplasmic retention of NF-kappa B by other cellular proteins renders the pathway unresponsive to activation.
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