Journal
CHEST
Volume 128, Issue 3, Pages 1483-1489Publisher
ELSEVIER
DOI: 10.1378/chest.128.3.1483
Keywords
chest radiography; echocardiography; oxygen saturation; pulmonary function; pulmonary hypertension; sarcoidosis
Categories
Ask authors/readers for more resources
Study objective: To differentiate the clinical, radiographic, and physiologic profile in patients with sarcoidosis with and without pulmonary hypertension. Design: Retrospective survey. Setting: Tertiary, care center. Patients: One hundred six patients with sarcoidosis were classified by, two-dimensional echocardiography into two groups: group 1, 54 patients with pulmonary hypertension; group 2, 52 patients without pulmonary, hypertension. Interventions: Patients underwent two-dimensional and Doppler echocardiography, chest radiography (CXR), pulmonary function testing, and arterial oxygen saturation determination, and the test results were compared between the two groups. Statistical analysis was performed using independent-sample t test and chi(2)test, as appropriate; p < 0.05 was considered to be significant. Results: Predicted spirometric values and lung diffusing capacity, were significantly lower in patients in group I compared to patients in group 2: FVC, 54% vs 64% (p = 0.0065), FEV1, 47% vs 61% (p = 0.0005), forced expiratory, flow, midexpiratory phase, 35% vs 52% (p = 0.0363), and single-breath diffusing capacity of the lung for carbon monoxide (DLCOSb), 39% vs 54% (p = 0.0001). Sixty, percent of patients in group I had radiographic Scadding stage 4 sarcoidosis, while no radiographic stage predominated in group 2. Arterial oxygen saturation, need for oxygen supplementation, and degree of desaturation after exercise did not differ between groups. Conclusions: The presence of pulmonary, hypertension in patients with sarcoidosis is associated with higher prevalence of stage 4 sarcoidosis by CXR and lower predicted spirometric and DLCOSb measurements.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available