Journal
APPLIED RADIATION AND ISOTOPES
Volume 63, Issue 3, Pages 329-332Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2005.03.005
Keywords
F-18-labelling; positron emission tomography (PET); [F-18]SFB; automated module synthesis
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The three-step radiosynthesis of N-succinimidyl 4-[F-18]fluorobenzoate ([F-18]SFB) was adapted to a remotely controlled synthesis module. After optimization of the reaction conditions, the final [F-18]SFB was obtained in decay-corrected radiochemical yields of 34-38% (related to [F-18]fluoride; n = 12) within a synthesis time of 68 min. The radiochemical purity was in the range of 93-96%. (c) 2005 Elsevier Ltd. All rights reserved.
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