Journal
EUROPEAN JOURNAL OF CANCER
Volume 41, Issue 14, Pages 2196-2202Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ejca.2005.06.018
Keywords
targeted chemotherapy; non-Hodgkin's lymphoma; LHRH receptor; cytotoxic LHRH analogue AN-207
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We determined by immunohistochemistry the presence of LHRH receptors in surgical specimens of human non-Hodgkin's lymphomas (NHL) and investigated the expression of LHRH receptors in two human NHL cell lines, RL and HT by RT-PCR, Western blot and radioligand binding studies. In in vivo experiments with nude mice bearing tumours of these NHL cell lines, the efficacy of cytotoxic LHRH analogue AN-207 and its cytotoxic radical AN-201 was examined. LHRH receptors were detected in 94.1% of the human NHL specimens and in both NHL cell lines. AN-207 significantly (P < 0.01) inhibited the growth of RL and HT tumours, while the non-targeted AN-201 had no effects. Blockade of the LHRH receptors with an excess of LHRH agonist Decapeptyl suppressed the antitumour effects of AN-207. Our findings indicate that LHRH receptors expressed in a high percentage of human NHL specimens can be used for effective targeted therapy with the cytotoxic LHRH analogue AN-207. (c) 2005 Elsevier Ltd. All rights reserved.
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