Journal
EXPERT OPINION ON BIOLOGICAL THERAPY
Volume 5, Issue 9, Pages 1245-1254Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14712598.5.9.1245
Keywords
abatacept; biological response modifiers; costimulatory blockade; CTLA4 immunoglobulin; rheumatoid arthritis
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T cell costimulation is believed to be crucial in orchestrating immune responses that lead to inflammation and destruction in rheumatoid arthritis (RA). Abatacept is a novel recombinant CTLA41g fusion protein that selectively modulates costimulation via interrupting the CD28:CD80/86 pathway, resulting in clownregulation of T cell activation and multiple ensuing effector mechanisms. Abatacept has been shown to be efficacious, either when given alone or in combination with methotrexate, in patients with active RA, including anti-TNF failures. Improvements in clinical signs and symptoms, slowing of radiological progression, and enhancement in patient function and pain have been reported in clinical trials. infusions were well-tolerated with a favourable safety profile similar to placebo and no appreciable immunogenicity. Abatacept is the first in a new class of biological response modifiers called costimulatory blockers.
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