Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 166, Issue 1-2, Pages 29-38Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2005.03.015
Keywords
beta-endorphin; splenocytes; cytotoxic factors; hypothalamus; enriched natural killer cells
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Funding
- NIAAA NIH HHS [AA12642] Funding Source: Medline
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The effects of ethanol and beta-endorphin (beta-EP) on productions of cytolytic factors granzyme 13, perform and IFN-gamma in splenic rat NK cells were determined. Intracranial administration of beta-EP increased protein and mRNA levels of cytolytic factors in NK cells. Chronic ethanol feeding reduced the basal and beta-EP-induced levels of cytolytic factors in NK cells. In vitro treatment of beta-EP on NK cells increased the levels of perforin, granzyme B and IFN-gamma and their mRNA transcripts, whereas ethanol pre-treatment prevented beta-EP effects on cytolytic factors in these cells. These results suggest that beta-EP and ethanol interact to regulate NK cell functions. (C) 2005 Elsevier B.V. All rights reserved.
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