Journal
ACTA BIOMATERIALIA
Volume 1, Issue 5, Pages 583-589Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2005.05.005
Keywords
blood coagulation; silicon oxycarbide glass; pyrolytic carbon
Funding
- NHLBI NIH HHS [1 R01 HL 69965-01] Funding Source: Medline
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Silicon oxycarbide (SiOxCy) glass compositions are shown to exhibit a variable propensity to contact activate coagulation of whole human blood plasma that depends on X:Y surface stoichiometry. SiOxCy exhibit activation properties similar to pyrolytic carbon (PC) over a broad range of X:Y ratios. Surface composition of SiOxCy glass powders prepared by pyrolysis of thermosetting polysilsequioxanes roughly correlated with total carbon concentration of precursor resins and could be significantly modified by etching in alkaline solutions. Results suggest that SiOxCy may offer unique properties as a substitute for PC in medical-device applications demanding excellent tribological properties, such as artificial heart valves. (c) 2005 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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