Journal
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
Volume 11, Issue 9, Pages 706-712Publisher
CARDEN JENNINGS PUBL CO LTD
DOI: 10.1016/j.bbmt.2005.05.015
Keywords
allogeneic stem cell transplantation; graft-versus-host disease; tumor necrosis factor alpha; interferon gamma
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Peripheral blood T cells were isolated from 19 allogeneic and 4 autologous stem cell transplant (SCT) recipients and assessed for tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma transcription by reverse transcription-polymerase chain reaction. Levels were compared with resting donor T-cell transcription levels. Increased production of TNF-alpha predicted for the onset of severe (grade II-IV) graft-versus-host disease (GVHD) (P =.001). Increased TNF-alpha (P =.025) and IFN-gamma (P =.001) transcription also independently predicted for the eventual onset of extensive chronic GVHD. Increased TNF-alpha or IFN-gamma transcription was not seen in either a syngeneic SCT recipient or 4 autologous SCT controls. These findings provide a means by which GVHD can be predicted before it is clinically evident, thus allowing for accurate diagnosis and monitoring of GVHD and possibly more cost-effective management of post-SCT immunosuppression. (c) 2005 American Society for Blood and Marrow Transplantation.
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