Journal
EUROPEAN JOURNAL OF HAEMATOLOGY
Volume 75, Issue 3, Pages 262-263Publisher
WILEY
DOI: 10.1111/j.1600-0609.2005.00499.x
Keywords
thrombocytosis in child; Philadelphia positive; imatinib
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Philadelphia-chromosome positive thrombocythemia without features of chronic myeloid leukemia in peripheral blood has been described in adults. It is rare in children. We present a case of Philadelphia positive thrombocythemia in a child who was managed with a combination of imatinib and hydroxyurea. Although a reduction in the BCR-ABL transcript was documented, the thrombocytosis was refractory to imatinib alone and required the addition of hydroxyurea.
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