Journal
CHINESE JOURNAL OF CHEMISTRY
Volume 23, Issue 9, Pages 1236-1240Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.200591236
Keywords
oxime ester; synthesis; anticancer activity
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A series of 2,3,4-trimethoxyacetophenoxime esters containing benzothiazole moiety were synthesized by the reaction of oxime with acyl chloride in alkaline medium. Their structures were established by elemental analysis, IR, and H-1 NMR spectra. The bioassay tests showed that these tide compounds exhibit moderate anticancer activity in vitro by MTT method and compounds 6c and 6d could inhibit ERK phosphorylation in NIH 3T3 cell induced by PDGF.
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