Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 13, Issue 17, Pages 5267-5273Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2005.05.068
Keywords
co-culture; induction of biosynthesis; libertellenones
Funding
- NCI NIH HHS [CA 67775, CA 44848] Funding Source: Medline
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The induction of biosynthesis of four new diterpenoids was observed following the addition of a marine alpha-proteobacterium to an established culture of the marine-derived fungus Libertella sp. The fungal strain and the marine bacterium, cultured alone, do not produce diterpenoid metabolites. The induced diterpenoids, libertellenones A-D, are cross-conjugated ketones of the pimarane class. The libertellenones show varying levels of cytotoxicity against the HCT-116 human adenocarcinoma cell line with libertellenone D being the most potent (IC50 = 0.76 mu M). (c) 2005 Elsevier Ltd. All rights reserved.
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