Journal
JOURNAL OF APPLIED TOXICOLOGY
Volume 25, Issue 5, Pages 440-443Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/jat.1077
Keywords
chromium; liver; oxidative stress; rats; vitamin B6
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The aim of this study was to examine the efficacy of vitamin B6 against chromium (Cr)-induced oxidative stress. Adult male albino Wistar rats (100-120 g) were used in this study. Potassium dichromate, a Cr VI compound, was administered at a dose of 127 mg kg(-1) p.o. Vitamin B6 (pyridoxine hydrochloride) was administered at a dose of 100 mg kg(-1) p.o. either alone or 12 h prior to Cr or simultaneously with Cr. Chromium treatment induced oxidative stress in the liver as measured by increased lipid peroxidation (LPO) and decreased vitamin C, vitamin E, glutathione (GSH), glutathione peroxidase (GPX), catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST) and glutathione reductase (GR). Both pre- and simultaneous treatments countered Cr-induced oxidative stress; pre-treatment was more effective than concurrent administration. The results demonstrate the antioxidant potential of vitamin B6. Copyright (C) 2005 John Wiley & Sons, Ltd.
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