Journal
INTERNATIONAL REVIEWS OF IMMUNOLOGY
Volume 35, Issue 5, Pages 399-414Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/08830185.2015.1068304
Keywords
chronic inflammation; fibrosis; hepatic fibrosis; innate lymphoid cells; interleukin; pulmonary fibrosis
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Funding
- Major State Basic Research Development Program of China [2013CB531503]
- National Natural Science Foundation of China [31170839, 30930086]
- Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) [10521]
- NSFC major collaborative project [81220108024]
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Fibrosis is a consequence of chronic inflammation and the persistent accumulation of extracellular matrix, for which the cycle of tissue injury and repair becomes a predominant feature. Both the innate and adaptive immune systems play key roles in the progress of fibrosis. The recently identified subsets of innate lymphoid cells (ILCs), which are mainly localize to epithelial surfaces, have been characterized as regulators of chronic inflammation and tissue remodeling, representing a functional bridge between the innate and adaptive immunity. Moreover, recent research has implicated ILCs as potential contributing factors to several kinds of fibrosis diseases, such as hepatic fibrosis and pulmonary fibrosis. Here, we will summarize and discuss the key roles of ILCs and their related factors in fibrotic diseases and their potential for translation to the clinic.
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