Journal
TRENDS IN GENETICS
Volume 21, Issue 9, Pages 492-495Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2005.06.013
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Network motifs, the recurring regulatory structural patterns in networks, can self-organize to produce networks because of the large ratio of genes to transcription factors (TFs) in genomes. We find a common design principle of these motifs: the TFs whose transcripts have short half-lives are significantly enriched in motifs and hubs. This enrichment becomes one of the driving forces for the emergence of the network scale-free topology, enables the network to adapt quickly to environmental changes and mitigates gene expression fluctuations. Motifs are classified into subtypes that are preferentially used in different cellular conditions.
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