Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 49, Issue 9, Pages 3944-3947Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.49.9.3944-3947.2005
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A doripenem population pharmacokinetic model and Monte Carlo simulations were utilized for dose regimen decision support for future clinical development. Simulation results predict that 500 mg of doripenem administered over 1 h every 8 h would be effective against bacterial strains with MICs less than 2 mu g/ml and that less susceptible strains could be treated with prolonged infusions.
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