Journal
CARDIOVASCULAR PATHOLOGY
Volume 14, Issue 5, Pages 265-268Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.carpath.2005.06.001
Keywords
Chagas' disease; chronic chagasic cardiomyopathy; heart transplantation; polymerase chain reaction; endomyocardial biopsy
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Polymerase chain reaction (PCR) has been used to detect microbiological agent recurrence after heart transplantation of viral-induced cardiomyopathies. We report a case of reactivation of Chagas' disease after heart transplantation in which parasites could be detected in the endomyocardial biopsy using hematoxylin-eosin-stained sections, immunohistochemistry, and PCR for Trypanosoma cruzi DNA. Interestingly, PCR results remained positive in the endomyocardial biopsy 53 days after the beginning of successful treatment, pointing to the possibility of chronic persistence of parasites in the myocardium after the reactivation of Chagas' disease. (c) 2005 Elsevier Inc. All rights reserved.
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