Journal
CELL CYCLE
Volume 4, Issue 9, Pages 1161-1165Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.4.9.1979
Keywords
Ran; RanGAP1; crm1; kinetochore; microtubule
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Funding
- Intramural NIH HHS [Z01 HD008740-06] Funding Source: Medline
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The Ran GTPase controls multiple mitotic processes in Xenopus egg extracts, including mitotic checkpoints, spindle assembly and post-mitotic nuclear envelope reassembly. We have analyzed Ran's role in somatic cells. We uncovered a novel mitotic role of Ran-GTP, involving the Crm1 nuclear export receptor. This pathway is an important mode of RanGTP function during mitosis in mammalian somatic cells, which mediates the recruitment of the RanGAP1/RanBP2 complex to kinetochores and maintains the microtubule-based fibers connecting kinetochores to spindle poles (k-fibers). Here we discuss potential implications of these findings for normal k-fiber assembly.
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