Journal
JOURNAL OF NATURAL PRODUCTS
Volume 68, Issue 9, Pages 1400-1403Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np0500528
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Funding
- NCRR NIH HHS [P20 RR016467, 2P20RR016467] Funding Source: Medline
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A collection of an undescribed marine sponge of the genus Plakortis yielded four new polyketide-derived metabolites, lehualides A-D (1 -4). The structures of compounds 1 -4 were elucidated by interpretation Of spectral data. Compound 2 demonstrated cytotoxicity against an ovarian cancer cell line, while compound 4 was active against both ovarian cancer and leukemia cell lines.
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