Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 130, Issue 5, Pages 747-751Publisher
WILEY
DOI: 10.1111/j.1365-2141.2005.05667.x
Keywords
aplastic anaemia; human leucocyte antigen-matched marrow grafts; cyclophosphamide/antithymocyte globulin conditioning
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Funding
- NCI NIH HHS [CA15704] Funding Source: Medline
- NHLBI NIH HHS [HL36444] Funding Source: Medline
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A total of 81 severe aplastic anaemia patients, aged 2-63 years, received human leucocyte antigen-matched related marrow grafts after cyclophosphamide + antithymocyte globulin followed by postgrafting methotrexate + ciclosporin. Median follow-up was 9.2 years. Ninety-six per cent of patients had sustained engraftment, 24% developed acute graft-versus-host disease (GVHD), grade 11 in all but two patients, and 26% developed chronic GVHD; all surviving patients eventually responded to immunosuppressive therapy. Six patients developed cancer: one fatal lymphoma and five carcinomas (all five patients are now free of cancer). Survival was 88%. The regimen appeared well tolerated and effective in heavily pretreated patients with aplastic anaemia.
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