Journal
REPRODUCTIVE TOXICOLOGY
Volume 20, Issue 3, Pages 353-367Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2005.04.010
Keywords
developmental origins of adult disease; embryo; nutritional programming; DNA methylation; human embryonic stem cells; folate
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Funding
- Medical Research Council [G113/30] Funding Source: Medline
- MRC [G113/30] Funding Source: UKRI
- Medical Research Council [G113/30] Funding Source: researchfish
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Our laboratory is evaluating whether an epigenetic mechanism involving alterations in DNA methylation can alter the trajectory of embryonic/fetal development in response to maternal nutrients. A similar mechanism may operate in embryo culture environments commonly used in human assisted conception. Since developmental studies on early human embryos in utero are obviously not possible, we have begun to investigate the utility of human,embryonic stern cells (hESC) to uncover potential programming mechanisms. This review highlights some of the advantages and problems associated with such a model and suggests that these issues are also broadly applicable to utility of hESC for more general toxicology and drug screening applications. (c) 2005 Elsevier Inc. All rights reserved.
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