Journal
PHYTOCHEMISTRY
Volume 66, Issue 17, Pages 2012-2031Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2005.04.023
Keywords
hydrolyzable tannins; polyphenols; classification of hydrolyzable tannins; hydrolyzable tannin oligomers; oxidized polyphenols; plant evolution; inhibition of peroxidation; radical scavenger; antimutagenicity; anti-tumor promotion; host-mediated antitumor activity; antiviral; activity
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The research began with an investigation of tannins from traditional medicinal plants and resulted in isolation and structure determination of hundreds of ellagitannins and dehydroellagitannins, as well as their oligomers and oxidized derivatives with various structures specific to each plant species. These polyphenols have been classified according to the stage of oxidative structural transformation and oligomerization, into types I-IV and I+ to IV+, etc. Parallels were found between their oxidative transformations and plant evolution. They were also classified by the linkage units between the monomers, into DOG, GOD, GOG and DOGOD types (D = Diphenoyl, G = Galloyl, O = Oxygen), etc. Besides their fundamental activities, e.g., reduction and anti-peroxidation properties, remarkable biological and pharmacological activities of various potencies have also been found, including, amongst others, inhibition of lipid-peroxidation, mutagenicity of carcinogens and tumor promotion, host-mediated antitumor effects specific to particular tannin structures, antiviral activity and potentiation of antibacterial activity. (c) 2005 Elsevier Ltd. All rights reserved.
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