Journal
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Volume 577, Issue 1-2, Pages 195-202Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mrfmmm.2005.04.005
Keywords
p53; nucleotide excision repair; global genomic repair; XPC; DDB2; DNA damage
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In response to DNA damage, the p53 tumor suppressor gene product is activated leading to the induction of several downstream cellular processes including cell cycle checkpoints, DNA repair or apoptosis. Experiments first performed in the Hanawalt laboratory identified a p53-dependent pathway affecting global genomic nucleotide excision repair. The mechanisms involved in this process include both transcriptional and post-translational regulation by p53 of the DDB2 and XPC gene products, two critical DNA damage recognition proteins required for GGR. A historical review of this work is presented. (C) 2005 Elsevier B.V. All rights reserved.
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