Sterically mediated two-dimensional architectures in aggregates of Au nanoparticles directed by phosphorothioate oligonucleotide-DNA

Sterically mediated aggregation of gold nanoparticles: 13 nm gold nanoparticles can be arrenged in a hexagonal, square, tirgonal, or linear manner (see figure) in two-dimensional (2D) aggregates linked by phosphorothiote oligo-DNA (PS oligo-DNA) of different lengths . The steric effect induced by the parallel orientation of the PS oligo-DNA helix on the particle surface is identified to be of vital importance in controlling the 2D architecture of the particles in the aggregates.