Journal
ONCOGENE
Volume 24, Issue 39, Pages 5976-5985Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1208978
Keywords
HTLV; leukemia; T-lymphocyte; cell cycle; transformation; immortalization; Tax; ATLL apoptosis
Ask authors/readers for more resources
The HTLV Tax protein is crucial for viral replication and for initiating malignant transformation leading to the development of adult T-cell leukemia. Tax has been shown to be oncogenic, since it transforms and immortalizes rodent. broblasts and human T-lymphocytes. Through CREB, NF-kappa B and SRF pathways Tax transactivates cellular promoters including those of cytokines (IL-13, IL-15), cytokine receptors (IL- 2R alpha) and costimulatory surface receptors (OX40/OX40L) leading to upregulated protein expression and activated signaling cascades ( e. g. Jak/STAT, PI3Kinase, JNK). Tax also stimulates cell growth by direct binding to cyclin-dependent kinase holenzymes and/or inactivating tumor suppressors (e.g. p53, DLG). Moreover, Tax silences cellular checkpoints, which guard against DNA structural damage and chromosomal missegregation, thereby favoring the manifestation of a mutator phenotype in cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available