Journal
CELL
Volume 122, Issue 5, Pages 789-801Publisher
CELL PRESS
DOI: 10.1016/j.cell.2005.06.025
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Funding
- MRC [G0400485] Funding Source: UKRI
- Medical Research Council [G0400485] Funding Source: researchfish
- Medical Research Council [G0400485] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
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Dietary heme iron is an important nutritional source of iron in carnivores and omnivores that is more readily absorbed than non-heme iron derived from vegetables and grain. Most heme is absorbed in the proximal intestine, with absorptive capacity decreasing distally. We utilized a subtractive hybridization approach to isolate a heme transporter from duodenum by taking advantage of the intestinal gradient for heme absorption. Here we show a membrane protein named HCP1 (heme carrier protein 1), with homology to bacterial metal-tetracycIine transporters, mediates heme uptake by cells in a temperature-dependent and saturable manner. HCP1 mRNA was highly expressed in duodenum and regulated by hypoxia. HCP1 protein was iron regulated and localized to the brush-border membrane of duodenal enterocytes in iron deficiency.
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