Journal
SCIENCE
Volume 309, Issue 5741, Pages 1739-1741Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1114580
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- NIAID NIH HHS [U54 AI057153, U54 AI057153-02, 1-U54-AI-057153, U54 AI057153-01] Funding Source: Medline
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The plague is caused by the bacterium Yersinia pestis. Plague bacteria are thought to inject effector Yop proteins into host cells via the type III pathway. The identity of the host cells targeted for injection during plague infection is unknown. We found, using Yop beta-lactamase hybrids and fluorescent staining of live cells from plague-infected animals, that Y. pestis selected immune cells for injection. In vivo, dendritic cells, macrophages, and neutrophils were injected most frequently, whereas B and T lymphocytes were rarely selected. Thus, it appears that Y. pestis disables these cell populations to annihilate host immune responses during plague.
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