Journal
FEBS LETTERS
Volume 579, Issue 22, Pages 5035-5039Publisher
WILEY
DOI: 10.1016/j.febslet.2005.07.091
Keywords
DNA; RNA; dialysis; binding; single-stranded poly(A); secondary structure
Funding
- NCI NIH HHS [CA35635] Funding Source: Medline
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The small molecule coralyne was found to bind preferentially and strongly to single-stranded poly(A) with an apparent association constant (K-a) of (1.8 +/- 0.3) x 10(6) M-1. Binding of coralyne to poly(A) is predominantly enthalpically driven with a stoichiometry of one coralyne per four adenine bases. Poly(A) forms a coralyne dependent secondary structure with a melting temperature of 60 degrees C, for the conditions of our study. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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