Journal
NEUROLOGY
Volume 65, Issue 5, Pages 745-747Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/01.wnl.0000174432.87383.87
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Funding
- NCRR NIH HHS [R01 RR16594-01A1, P41-RR14075] Funding Source: Medline
- NINDS NIH HHS [NS042861] Funding Source: Medline
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The authors studied presymptomatic individuals with the Huntington disease (HD) mutation to determine whether cortical thinning was present. They found thinning that was regionally selective, semi-independent of striatal volume loss, and correlated with cognitive performance. Early, extensive cortical involvement occurs during the preclinical stages of HD.
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