Journal
ORGANIC LETTERS
Volume 7, Issue 19, Pages 4117-4120Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol051396s
Keywords
-
Categories
Funding
- NIGMS NIH HHS [GM-62924] Funding Source: Medline
Ask authors/readers for more resources
Psymberin is a sponge-derived natural product that shows striking selectivity as a cytotoxic agent. Conformational mobility has precluded stereochemical assignment for the acyl fragment of this molecule (psymberic acid) by NMR. Herein we report stereoselective syntheses of all four stereoisomers of psymberic acid. A comparison of the acid-mediated cyclization products of these compounds to the product of psymberin's acidic methanolysis showed the stereochemical configuration of this fragment to be 4S, 5S.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available