4.8 Article

Cu(I)-catalyzed highly exo-selective and enantioselective [3+2] cycloaddition of azomethine ylides with acrylates

Journal

ORGANIC LETTERS
Volume 7, Issue 19, Pages 4241-4244

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol0516925

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A novel Cu(l)-catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylides with acrylates has been developed. Up to 98/2 exotendo selectivity and up to 98% enantiomeric excess have been achieved.

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