Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 39, Issue 3-4, Pages 349-363Publisher
ELSEVIER
DOI: 10.1016/j.jpba.2005.03.040
Keywords
NSAIDs; COX-2 inhibitors; bulk drugs; pharmaceuticals; biological fluids; spectrophotometry; chromatography
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An extensive survey of the literature published in various analytical and pharmaceutical chemistry related journals has been conducted and the instrumental analytical methods which were developed and used for determination of COX-2 inhibitors in bulk drugs, formulations and biological fluids have been reviewed. This review covers the time period from 1995 to 2004 during which 138 analytical methods including all types of spectrophotmetric and chromatographic techniques were reported. HPLC with UV detection was found to be the technique of choice for many workers and more than 100 methods were based on LC and UV. A critical analysis of the reported data has been carried out and the present state-of-art of the analytical techniques for determination of celecoxib, rofecoxib, etoricoxib, etodolac, nimesulide and meloxicam has been discussed. (c) 2005 Elsevier B.V. All rights reserved.
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