Journal
FEMS MICROBIOLOGY LETTERS
Volume 250, Issue 2, Pages 271-277Publisher
OXFORD UNIV PRESS
DOI: 10.1016/j.femsle.2005.07.019
Keywords
biofilm formation; synergy; Treponema denticola; Porphyromonas gingivalis; flagella; cytoplasmic filament; fimbriae; gingipain; motile
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Funding
- NIDCR NIH HHS [DE09821] Funding Source: Medline
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Biofilm formation is an important step in the etiology of periodontal diseases. In this study, in vitro biofilm formation by Treponema denticola and Porphyromonas gingivalis 381 displayed synergistic effects. Confocal microscopy demonstrated that P. gingivalis attaches to the substratum first as a primary colonizer followed by coaggregation with T denticola to form a mixed biofilm. The T denticola flagella mutant as well as the cytoplasmic filament mutant were shown to be essential for biofilm formation as well as coaggregation with P. gingivalis. The major fimbriae and Arg-gingipain B of P. gingivalis also play important roles in biofilm formation with T. denticola. (c) 2005 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
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