4.8 Article

Samarium barbier reactions of α-iodomethyloxazoles and thiazoles with aliphatic aldehydes

Journal

ORGANIC LETTERS
Volume 7, Issue 19, Pages 4099-4102

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol051345v

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Funding

  1. NIGMS NIH HHS [GM-41560] Funding Source: Medline

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The reductive coupling of substituted alpha-iodomethyloxazoles and thiazoles with aliphatic aldehydes under Barbier conditions provides an effective method for the direct incorporation of intact heterocyclic systems.

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