Journal
JOURNAL OF IMMUNOLOGY
Volume 175, Issue 6, Pages 3502-3507Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.175.6.3502
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Critical to the development of an effective HIV vaccine is the identification of adaptive immune responses that prevent infection or disease. In this study we demonstrate in a relevant nonhuman primate model of AIDS that the magnitude of vaccine-induced virus-specific CD8(+) central memory T cells (T-CM), but not that of CD8(+) effector memory T cells, inversely correlates with the level of SIVmac251 replication, suggesting their pivotal role in the control of viral replication. We propose that effective preventive or therapeutic T cell vaccines for HIV-1 should induce long-term protective central memory T cells.
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