Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 70, Issue 19, Pages 7761-7764Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo050163b
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- NIGMS NIH HHS [GM-28384] Funding Source: Medline
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[GRAPHICS] 3,5-Disubstituted isoxazoles are obtained in good yields by a convenient one-pot, three-step procedure utilizing a regioselective copper(I)-catalyzed cycloaddition reaction between in situ generated nitrile oxides and terminal acetylenes. Most functional groups do not interfere with the reaction, which can be performed in aqueous solvents without protection from oxygen. Since all reagents are used in stoichiometric amounts, formation of byproducts is minimized.
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