Journal
SYNLETT
Volume -, Issue 15, Pages 2335-2336Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2005-872670
Keywords
Pudovik reaction; dialkylphosphite; phosphate esters; phospha-Brook rearrangement
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Addition of dialkylphosphites to aromatic aldehydes (Pudovik reaction) by treatment with a base results in two different possible reaction pathways depending on the solvent used. Apolar solvents give the normal Pudovik adduct, whereas the use of DBU in a polar solvent allows the formation of a phosphate ester via phospha-Brook rearrangement of the intermediate hydroxyphosphonate.
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