The potential of phage display virions expressing malignant tumor specific antigen MAGE-A1 epitope in murine model

The tumor specific antigen epitope melanoma antigen A1(161-169) (MAGE-A1(161-169)) was displayed on the major protein (pVIII) of the filamentous bacteriophage (fd). The immune responses of the phage display particles expressing MAGE-A1161-169 in mice were studied. Using phage display particles as vaccine was effective in affording protection from tumor growth, inducing growth control of established tumors and prolonging survival of tumor-bearing mice. The hybrid phage particles elicited MAGE-A1(161-169) specific CTL responses, NK activity and DTH. Our results showed that the phage display particles might be a new vaccine candidate for tumor-associated antigen epitope in cancer immunotherapy. (c) 2005 Published by Elsevier Ltd.