Journal
VACCINE
Volume 23, Issue 40, Pages 4860-4866Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2005.05.024
Keywords
tumor specific antigen; anti-tumor immunity; bacteriophage display
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The tumor specific antigen epitope melanoma antigen A1(161-169) (MAGE-A1(161-169)) was displayed on the major protein (pVIII) of the filamentous bacteriophage (fd). The immune responses of the phage display particles expressing MAGE-A1161-169 in mice were studied. Using phage display particles as vaccine was effective in affording protection from tumor growth, inducing growth control of established tumors and prolonging survival of tumor-bearing mice. The hybrid phage particles elicited MAGE-A1(161-169) specific CTL responses, NK activity and DTH. Our results showed that the phage display particles might be a new vaccine candidate for tumor-associated antigen epitope in cancer immunotherapy. (c) 2005 Published by Elsevier Ltd.
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