Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 45, Issue 1, Pages 1-6Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2005.06.014
Keywords
rifampicin; PLGA; phagocytosis; lung surfactants; tuberculosis
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Pulmonary surfactants little affected the release ratio of rifampicin from rifampicin-loaded poly(lactide-co-glycolide) PLGA microspheres. The release ratio of rifampicin was depending on pH of pulmonary surfactant solution, showing that rifampicin-loaded PLGA microspheres have an ideal property to deliver rifampicin into alveolar macrophages inside of which Mycobacterium tuberculosis bacilli reside and to kill them. That is, little amount of rifampicin is released in alveolar lining liquid before the microspheres are phagocytosed. by alveolar macrophages, then rifampicin is released in phagosome or cytoplasm, but little amount of ritampicin is released in lysosome of alveolar macrophages after the microspheres are internalized. Pulmonary surfactants also little affected the changes in molecular weight of residual PLGA during its hydrolytic degradation process. From the electrophoretic mobility measurements of PLGA microspheres, it was shown that pulmonary surfactants changed the surface charge density of PLGA microspheres by adsorbing on their surfaces. (c) 2005 Elsevier B.V. All rights reserved.
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