Journal
TETRAHEDRON
Volume 61, Issue 39, Pages 9331-9337Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2005.07.060
Keywords
copper(I)-catalyzed; three-component reaction; water; Huisgen cycloaddition
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A copper(l)-catalyzed three-component reaction to form (1 -substituted- 1H- 1,2,3-triazol-4-ylmethyl)-dialkylamines based on the Huisgen cycloaddition using amine, propargyl halide and azide in water was proposed. The process showed considerable synthetic advantages in terms of high atom economy, low environmental impact, atmospheric oxygen, wide substrate scope, mild reaction condition and good yields. (c) 2005 Published by Elsevier Ltd.
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