Journal
TETRAHEDRON LETTERS
Volume 46, Issue 39, Pages 6641-6644Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2005.07.158
Keywords
P-chiral dinucleoside phosphorothioate; oligonucleotide phosphorothioate; PS-DNA; S-protection; oligonucleotide synthesis
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Appropriately protected, diastereomerically pure dinucleoside phosphorothioates, obtained by the stereocontrolled oxathiaphospholane method, were S-alkylated with 2-nitrobenzyl bromide and then converted into their 3 '-0-phosphoramidites. The corresponding S-protected dinucleotide building blocks were successfully used for the synthesis of oligonucleotides containing P-stereodefined phosphorothioate bonds at preselected positions. (c) 2005 Elsevier Ltd. All rights reserved.
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