Journal
NATURE NEUROSCIENCE
Volume 8, Issue 10, Pages 1292-1294Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1532
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L7-PKCl transgenic mice, which lack parallel fiber - Purkinje cell long-term depression (LTD), were tested with two different mazes to dissociate the relative importance of declarative and procedural components of spatial navigation. We show that L7-PKCI mice are deficient in acquisition of an adapted goal-oriented behavior, part of the procedural component of the task. This supports the hypothesis that cerebellar LTD may subserve a general sensorimotor adaptation process shared by motor and spatial learning functions.
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