Journal
IMMUNITY
Volume 23, Issue 4, Pages 397-407Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2005.09.004
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Funding
- NCI NIH HHS [CA102793] Funding Source: Medline
- NHLBI NIH HHS [HL071932, HL43340] Funding Source: Medline
- NIAID NIH HHS [AI54917] Funding Source: Medline
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Mature recirculating B cells are generally assumed to exist in follicular niches in secondary lymphoid organs, and these cells mediate T-dependent humoral immune responses. We show here that a large proportion of mature B lymphocytes occupy an anatomically and functionally distinct perisinusoidal niche in the bone marrow. Perisinusoidal B cells circulate freely, as revealed by parablosis studies. However, unlike their counterparts in the follicular niche, these cells are capable of being activated in situ by blood-borne microbes in a T-independent manner to generate specific IgM antibodies. The bone marrow represents a unique type of secondary lymphoid organ in which mature B cells are strategically positioned in the path of circulating microbes.
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