Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 28, Issue 10, Pages 1142-1146Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/BF02972976
Keywords
Saussurea calcicola; Compositae; sesquiterpene lactone; cytotoxicity
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Seven sesquiterpene lactones were isolated by the chromatographic separation of the MeOH extract of the aerial parts of Saussurea calcicola (Compositae). Their structures were determined spectroscopically to be cynaropicrin (1), arguerin B (2), cebellin F (3), 8 alpha-hydroxy-11 alpha, 13-dihydrozaluzanin C (4), desacylcynaropicrin (5), 3 beta-hydroxy-8 alpha-epoxymethylacriloiloxy-4(15),10(14),11(13)-trien-guaian-6,12-olide (6), and kandavanolide (7). Compounds 1 and 2 showed significant cytotoxicity against five cultured human tumor cell lines with ED50 values ranging from 0.23 similar to 1.72 mu g/mL.
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